Direct differentiation of cardiomyocytes from human embryonic stem cells

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United States of America Patent

SERIAL NO

11644790

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Abstract

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The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential minerals selected from the group including transferrin and selenium, small molecules selected from the group including a p38 MAPK inhibitor such as SB203580 and protein growth factors of the FGF, IGF and BMP families such as but not limited to IGF1, FGF2, BMP2, BMP4 and BMP6. and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from stem cells is also provided wherein the media contains these factors. The use of cardiomyocytes and cardiac progenitors produced by the directed differentiation in transplantation and screening for cardiac compounds is also provided.

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Patent Owner(s)

Patent OwnerAddress
ES CELL INTERNATIONAL PTE LTD60 BIOPOLIS STREET #01-03 GENOME SINGAPORE 138672

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davidson, Bruce Paul Singapore, SG 5 37
Graichen, Ralph Eberhard Singapore, SG 4 29
Mummery, Christine Lindsay DJ Bilthoven, NL 11 114
Sun, William Singapore, SG 10 125
Xuiqin, Xu Singapore, SG 1 6
Zweigerdt, Robert Singapore, SG 8 29

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