BIOMARKERS FOR ALS
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United States of America Patent
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Issued Date -
Aug 30, 2007
app pub date -
Dec 5, 2006
filing date -
Dec 5, 2005
priority date (Note) -
Abandoned
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Abstract
Provided are methods for diagnosing sporadic and familial forms of amyotrophic lateral sclerosis ('ALS') that detect conformers or conformer patterns of the copper-zinc superoxide dismutase-1 ('SOD-1') enzyme that are common to sporadic or familial ALS individuals but distinct from SOD-1 conformers of normal individuals. Methods of identifying candidate drugs that modulate SOD-1 conformer formation also are provided.
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