Cyclic quaternary amino derivatives as modulators of chemokine receptors
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United States of America Patent
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Issued Date -
Aug 23, 2007
app pub date -
Apr 8, 2004
filing date -
Apr 16, 2003
priority date (Note) -
Abandoned
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Abstract
Compounds of formula (1) wherein, m, n, R.sup.1, R.sup.2, R.sup.a, ALK.sup.3, E and Y are as defined in the claims, being potent and selective inhibitors of chemokine binding to the CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammatory, autoimmune and immurforegulatory disorders such as rheumatoid arthritis.
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