Channel blocking compounds
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United States of America Patent
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Issued Date -
Aug 16, 2007
app pub date -
Aug 13, 2004
filing date -
Aug 15, 2003
priority date (Note) -
Abandoned
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Abstract
The invention relates to compositions and associated methods and uses that contain lolitrem compounds containing the moiety shown in structure (I) or derivatives thereof for ion channel antagonist applications, particularly BK channel antagonist applications. Preferred compounds include lolitrem B, 31-epilolitrem B, lolitriol and lolitrem E. For lolitrem B, a particularly strong and long acting blocking effect is identified.
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