Process for the preparation of optically pure 4-hydroxy-2-oxo-1-pyrrolidine acetamide
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United States of America Patent
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Issued Date -
Aug 9, 2007
app pub date -
May 25, 2005
filing date -
May 25, 2004
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Abandoned
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Abstract
A process for the preparation of chiral 4-hydroxy-2-oxo-1-pyrrolidine acetamide includes adding sodium cyanide together with citric acid to a solution of chiral epichlorohydrin to obtain chiral 3-chloro-2-hydroxypropionitrile by ring opening reaction of the chiral epichlorohydrin, reacting the obtained product with an alcohol containing hydrochloride gas to obtain chiral 4-chloro-3-hydroxybutyric acid ester, and reacting the obtained product in a presence of a base with glycinamide or with glycine ester accompanied by ammonolysis with ammonia to produce the targeted chiral 4-hydroxy-2-oxo-1-pyrrolidine acetamide.
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