Method for the linkage of bifunctional chelating agents and (radioactive) transition metal complexes to proteins and peptides
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United States of America Patent
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Issued Date -
Aug 9, 2007
app pub date -
Jun 2, 2004
filing date -
Jun 3, 2003
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Abandoned
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Abstract
The present invention relates to a method for radioactive labeling of a protein or peptide, by providing a protein or peptide having at least one glutamine or lysine residue; adding a metal chelating agent having at least one lysine or glutamine residue, respectively, which metal chelating agent is optionally complexed with a radioactive or paramagnetic metal; reacting the protein or peptide and metal chelating agent in the presence of a transglutaminase to obtain a protein or peptide with a metal chelating group covalently bound thereto, and optionally complexing the metal chelating group with a radioactive or paramagnetic metal. The invention also relates to proteins and peptides thus labeled and to proteins and peptides that have been coupled to a metal chelating agent but not yet labeled.
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