METHODS OF TREATING PROTEINURIA BY REDUCING DOUBLE-STRANDED DNA ANTIBODIES
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app pub date -
Dec 20, 2006
filing date -
Mar 10, 2005
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Abstract
The invention provides methods of treating proteinuria in an individual such as human by administering an effective amount of an agent that reduces the level of anti-dsDNA antibodies (such as a dsDNA epitope as in the form of an epitope-presenting carrier or an epitope-presenting valency platform molecule like LJP 394) to the individual. The invention also provides methods of determining responsiveness of the individual to (or selecting an individual for continuing) treatment of an agent that reduces anti-dsDNA antibodies by determining reduction of proteinuria after a certain period of time upon initiation of the treatment.
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