Activation of hypoxia-inducible gene expression
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United States of America Patent
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Issued Date -
Jul 26, 2007
app pub date -
Nov 8, 2004
filing date -
Nov 7, 2003
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Abstract
The present invention relates to the elucidation of specific molecular features of endogenous 2-oxoacid molecules and their derivatives for activating hypoxia-inducible gene expression by inactivating hypoxia-inducible factor hydroxylating enzymes. This invention identifies agents that can be used to induce tissue vascularization, treat anemias, induce tolearance to stroke and heart attacks, improve tissue healing and improve organ transplantation.
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