Ribonucleic acid compound and method of liquid-phase synthesis of oligonucleic acid compound
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Issued Date -
Jul 26, 2007
app pub date -
Jan 26, 2005
filing date -
Jan 27, 2004
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Abstract
A novel phosphotriesterified ribonucleic acid compound which is important for liquid-phase synthesis of oligo-RNA is provided. Examples of the ribonucleic acid compound of the invention may include ribonucleic acid compounds represented by the following general formula: (wherein B represents adenine, guanine, cytosine or uracil or a modified form thereof; R.sup.21 represents aryl which may be substituted or a monocyclic or bicyclic heterocyclic group which may be substituted; R.sup.20 represents H or alkyl which may be substituted; and R.sup.1 represents a protecting group which can be removed at 90% or more at a temperature in the range from 0.degree. C. to 60.degree. C. under acidic conditions at a pH value from 2 to 4 within 24 hours).
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