Substrates and methods for assaying deubiquitinating enzymes
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United States of America Patent
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Issued Date -
Jul 19, 2007
app pub date -
Jan 12, 2007
filing date -
Jan 13, 2006
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Abandoned
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Abstract
The invention relates to substrates and methods suitable for assaying deubiquitinating enzyme activity, and in particular for screening inhibitors of enzymes involved in removal of mono or poly-ubiquitin chains from a target protein as well as inhibitors of ubiquitin precursors. Such inhibitors may have utility in the treatment of disease states associated with ubiquitin processing as well as proteolysis.
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