METHODS OF IN VITRO PROPAGATION AND DETECTION OF INFECTIOUS PRION
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United States of America Patent
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Issued Date -
Jul 19, 2007
app pub date -
Dec 1, 2006
filing date -
Dec 8, 2005
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Abandoned
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Abstract
Methods for the in vitro propagation of infectious prions (PrP.sup.Sc) are provided. Follicular dendritic cells (FDCs) are cultured with B cells and infected with prions. Methods of detecting infectious prions (PrP.sup.Sc) in an animal or human are also provided. Peripheral blood B cells are collected from an animal or human suspected of being infected with infections prions, cultured with follicular dendritic cells, and the presence of infectious prions is detected.
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