3-alkylaryl aspartate compounds and their use for selective enhancement of synaptic transmission
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United States of America Patent
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Issued Date -
Jun 21, 2007
app pub date -
Oct 21, 2005
filing date -
Oct 21, 2004
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Abstract
The present invention provides an L-aspartate derivative compound represented by the following structure wherein Ar represents an aromatic group; L represents a linking moiety; R represents hydrogen, alkyl, aryl, or heteroaryl; and indicates that the stereochemistry at the 3-position can be R or S. The compounds of the invention are useful for selectively inhibiting EAAT3 and for enhancing synaptic transmission. Additionally, the inventive compounds can be used to treat a patient suffering from Alzheimers disease or a neuropathy or a neurodegenerative disease in which L-glutamate transporter activity is involved in the onset of the disease.
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