Method for producing viral vectors
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United States of America Patent
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Issued Date -
Jun 21, 2007
app pub date -
Jan 20, 2005
filing date -
Jan 22, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention provides methods for producing viruses, whose propagation depends on the cleavage of viral protein by a protease, in a manner independent of the protease. The methods of the present invention for producing viruses comprise producing viruses in the presence of a modified viral protein in which the protease cleavage sequence is changed to a cleavage sequence for an alternative protease. Viral vectors can be more efficiently produced by replacing the protease cleavage sequence with a cleavage sequence for a protease expressed endogenously in virus-producing cells. The methods of the present invention enable the production of high titer viruses using a wide variety of cells.
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