Methods for producing blood products from pluripotent cells in cell culture

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United States of America Patent

APP PUB NO 20070141703A1
SERIAL NO

10579712

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides methods for in vitro production of clinically useful quantities of differentiated human blood cells. In various embodiments of the present invention, immortal pluripotent cells are used to produce differentiated blood cell populations using a cell production device. In a specific embodiment, the device is a sequential series of bioreactors utilizing growth media containing specific combinations of maintenance-, proliferation- or differentiation-promoting factors that maintain, expand and promote the maturation and differentiation of the desired cell types. The immortal pluripotent cells can optionally be genetically modified so as to remove histcompatibility or blood group antigens.

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Patent Owner(s)

Patent OwnerAddress
AUSTRALIAN STEM CELL CENTRE LTDMONASH UNIVERSITY WELLINGTON ROAD GROUND FLOOR BUILDING 75 (STRIP) CLAYTON VICTORIA 3800

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Elefanty, Andrew George Surrey Hills, AU 2 113
Livesey, Stephen Anthony Victoria, AU 3 41
Stadler, Elizabeth Siewsun Surrey Hills, AU 1 37
Stanley, Edouard Guy Ascot Vale, AU 6 121

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