Serum-free expansion of cells in culture
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United States of America Patent
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Issued Date -
Jun 7, 2007
app pub date -
Nov 27, 2006
filing date -
Nov 28, 2005
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Abstract
Methods and agents are disclosed for modulating the interaction of .beta.-catenin or .gamma.-catenin with CBP or p300. Agents that increase the binding of CBP to .beta.-catenin are associated with enhancing the .beta.-catenin-related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem cells, as well as embryonic stem cells.
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