Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis
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United States of America Patent
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Issued Date -
May 31, 2007
app pub date -
Aug 31, 2006
filing date -
Sep 1, 2005
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Abstract
The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and/or testing. The inventive methods include analysis of the fragment size distribution of cell-free fetal DNA isolated from amniotic fluid. The inventive methods allow for rapid screening of fetal characteristics such as chromosomal abnormalities and for prenatal diagnosis of a variety of diseases and conditions. Since the new methods do not require cell culture, they can be performed more rapidly than conventional fetal karyotypes.
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