Method for cleaving and deglycosylating antibodies to promote ligand binding
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United States of America Patent
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app pub date -
Jan 5, 2007
filing date -
Oct 5, 2004
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Abstract
The present invention details methods to detect glycoproteins in samples to identify a disease state. In particular, an improved sandwich assay is described, using both an antibody and an array of lectins. Methods for increasing the efficiency of interaction of an antibody with a ligand by cleaving the antibody to remove the carbohydrate moiety, and orienting the cleaved fragment on a matrix to enhance recognition of a ligand are also described. Methods of differentiating pregnancy-derived and disease derived samples are also described.
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