Antibodies to the propeptide of candida albicans and methods of use
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United States of America Patent
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app pub date -
Nov 21, 2006
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Sep 28, 2000
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Abstract
Antibodies and agents which can bind to the propeptide of the Int1p protein of yeast microorganisms such as Candida albicans are provided which can be useful in methods for treating or preventing infections arising from such microorganisms. Microorganisms expressing the Int1p protein, such as C. albicans and S. cerevisiae, can immunomodulate host cells which allows infections of these microorganisms to thrive and become virulent. The present invention provides peptide regions involved in the activation of the Int1p protein that can provide a method of disrupting said activation to treat or prevent infection by microorganisms expressing the int1p protein. In one preferred embodiment, an antibody or agent which can bind to the propeptide or other region of the Int1p protein from C. albicans is utilized in methods to prevent or treat infections caused by C. albicans or other microorganisms expressing the Int1p protein.
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