Anti-Tumor Methods Using Multi Drug Resistance Independent Synthetic HSP90 Inhibitors
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United States of America Patent
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Issued Date -
May 10, 2007
app pub date -
Sep 25, 2006
filing date -
Sep 23, 2005
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Abstract
The present invention provides a method of treating an individual having an HSP90 mediated disorder comprising administering to said individual a pharmaceutical composition comprising a pharmaceutically effective amount of a synthetic heterocyclic HSP90 inhibitor, wherein the activity of the HSP90 inhibitor is substantially independent of multi drug resistance. In one embodiment, the activity of the HSP90 inhibitor is substantially independent of P-gp and MRP expression.
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