Immunotherapy
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United States of America Patent
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app pub date -
Oct 10, 2003
filing date -
Oct 14, 2002
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Abandoned
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Abstract
The invention provides an improved method of inducing an immune response against targeted cells. Using gene therapy to express both a toxin or prodrug converting enzyme as a means of killing a targeted cell type and also stress response protein (in particular, a heat shock protein) enhances the subsequent immune response directed against such cells. The method is particularly applicable to inducing an immune response against cancer cells. Also provided are polynucleotides, products and vectors for use in such a method.
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