Minus strand rna virus vector carrying gene modified in high mutation region
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United States of America Patent
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Issued Date -
May 10, 2007
app pub date -
Jun 30, 2004
filing date -
Jun 30, 2003
priority date (Note) -
Abandoned
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Abstract
The present invention provides minus-strand RNA viruses carrying a foreign gene that has a partial sequence corresponding to part of the minus-strand RNA virus E sequence and where the partial sequence has been altered. A foreign gene comprising such a partial E sequence is found to undergo mutations at high frequencies when the gene is carried by a minus-strand RNA virus. The generation of mutations in the gene carried by the minus-strand RNA virus can be prevented by altering the foreign gene sequence so as to not contain this sequence.
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