Methods and means for the treatment of disorders associated with cellular senescence

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United States of America Patent

APP PUB NO 20070099186A1
SERIAL NO

10554878

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention relates to mechanisms of cellular senescence and, in particular, to the role of DNA repair and DNA damage checkpoint pathways in the induction and maintenance of the senescent state. Methods and means of inducing cell cycle progression in senescent cells by inhibiting DNA damage checkpoint pathways are provided herein. These methods and means provide agents and therapies for the treatment of senescent associated disorders.

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Patent Owner(s)

Patent OwnerAddress
KUDOS PHARMACEUTICALS LIMITED1 FRANCIS CRICK AVENUE CAMBRIDGE BIOMEDICAL CAMPUS CAMBRIDGE CB2 0AA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
D'Adda, Di Fagagna Fabrizio Cambridge, GB 7 8
Jackson, Stephen Cambridge, GB 32 385
Reaper, Philip Michael Cambridge, GB 32 1123

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