Glucocorticoid modulation of nucleic acid-mediated immune stimulation
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United States of America Patent
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Issued Date -
Mar 8, 2007
app pub date -
Aug 28, 2006
filing date -
Aug 26, 2005
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Abandoned
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Abstract
The present invention provides methods for minimizing or inhibiting immune responses to immunostimulatory nucleic acids by pretreating with one or more doses of a glucocorticoid prior to nucleic acid administration. The nucleic acids are typically administered using a lipid-based carrier system such as a nucleic acid-lipid particle or liposome. As a result, patients following a glucocorticoid dosing regimen advantageously benefit from nucleic acid therapy without suffering any of the immunostimulatory side-effects associated with such therapy.
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