Compositions and methods for modulating connexin hemichannels
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United States of America Patent
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app pub date -
Aug 9, 2006
filing date -
Jan 29, 2002
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Abstract
Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.
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