Method of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular agonist
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
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N/A
Issued Date -
Feb 15, 2007
app pub date -
Jun 9, 2004
filing date -
Jun 9, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention relates to methods of inhibiting receptor tyrosine kinases by utilizing a combination of both an extracellular and an intracellular RTK antagonist. The extracellular RTK antagonist is a biological molecule or a small molecule that inhibits activation of the receptor tyrosine kinase by interacting with the extracellular binding region of the receptor. The intracellular RTK antagonist is a biological molecule or small molecule that inhibits tyrosine kinase activity of the receptor tyrosine kinase by interacting with the receptor's intracellular region bearing a kinase domain or by interacting with an intracellular protein involved in the signaling pathway of the receptor tyrosine kinase. The present invention also provides methods of treating tyrosine kinase-dependent diseases, and compositions for use in such methods thereof, by administering a combination of both an extracellular and an intracellular RTK antagonist.
First Claim
all claims..Other Claims data not available
Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
WAKSAL SAMUEL | Not Provided |
International Classification(s)

- 2004 Application Filing Year
- A61K Class
- 10035 Applications Filed
- 3484 Patents Issued To-Date
- 34.72 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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Waksal, Samuel | Minersville, PA | 8 | 12 |
# of filed Patents : 8 Total Citations : 12 |
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Patent Citation Ranking
- 0 Citation Count
- A61K Class
- 0 % this patent is cited more than
- 18 Age
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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