Method of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular agonist

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United States of America Patent

APP PUB NO 20070036795A1
SERIAL NO

10560209

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to methods of inhibiting receptor tyrosine kinases by utilizing a combination of both an extracellular and an intracellular RTK antagonist. The extracellular RTK antagonist is a biological molecule or a small molecule that inhibits activation of the receptor tyrosine kinase by interacting with the extracellular binding region of the receptor. The intracellular RTK antagonist is a biological molecule or small molecule that inhibits tyrosine kinase activity of the receptor tyrosine kinase by interacting with the receptor's intracellular region bearing a kinase domain or by interacting with an intracellular protein involved in the signaling pathway of the receptor tyrosine kinase. The present invention also provides methods of treating tyrosine kinase-dependent diseases, and compositions for use in such methods thereof, by administering a combination of both an extracellular and an intracellular RTK antagonist.

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Patent Owner(s)

Patent OwnerAddress
WAKSAL SAMUELNot Provided

International Classification(s)

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  • 2004 Application Filing Year
  • A61K Class
  • 10035 Applications Filed
  • 3484 Patents Issued To-Date
  • 34.72 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances20042005200620072008200920102011201220132014201520162017201820192020202120220255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Waksal, Samuel Minersville, PA 8 12

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges30718326412821326750302016134901 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +010020030040050060070080090010001100120013001400150016001700180019002000

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