Chemoradiotherapy with TS-1/camptothecins
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United States of America Patent
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Issued Date -
Feb 15, 2007
app pub date -
Aug 3, 2006
filing date -
Aug 11, 2005
priority date (Note) -
Abandoned
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Abstract
An antitumor agent for chemoradiotherapy of rectal cancer comprising a combination of TS-1 (a combination drug of tegafur, gimeracil, and oteracil potassium at a 1:0.4:1 molar ratio) and CPT-11 (irinotecan hydrochloride). The antitumor agent of the invention can achieve marked tumor volume reduction without causing major side effects, especially by coadministering it with preoperative radiation therapy. The volume of even large tumors that are refractory to surgical resection can be reduced by coadministering the antitumor agent of the invention with preoperative radiation therapy, making the subsequent surgical resection of the tumor easier.
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