1,3 Aclyated 24-keto-vitamin d3 compounds and methods of use thereof
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United States of America Patent
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Issued Date -
Feb 8, 2007
app pub date -
Apr 30, 2004
filing date -
Apr 30, 2003
priority date (Note) -
Abandoned
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Abstract
The invention provides 1,3 acylated, 24-keto vitamin D.sub.3 compounds of formula I: wherein: X.sub.1 and X.sub.1 are each independently H.sub.2 or .dbd.CH.sub.2, provided X.sub.1 and X.sub.1 are not both .dbd.CH.sub.2; R.sub.1 and R.sub.2 are each independently, hydroxyl, OC(O)C.sub.1-C.sub.4 alkyl, OC(O)hydroxyalkyl, OC(O)haloalkyl, provided that R.sub.1 and R.sub.2 are not both hydroxyl; R.sub.3 and R.sub.4 are each independently hydrogen, C1-C4 alkyl, hydroxyalkyl, or haloalkyl, or R.sub.3 and R.sub.4 taken together with C.sub.20 form C.sub.3-C.sub.6 cylcoalkyl; and R.sub.5 and R.sub.6 are each independently C.sub.1-C.sub.4 alkyl, hydroxyalkyl, or haloalkyl; and pharmaceutically acceptable esters, salts, and prodrugs thereof. Methods for using the compounds to treat vitamin D.sub.3 associated states, and phar,aceutical compositions containing the compounds are also disclosed.
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