Treating diabetes with glucagon-like peptide-1 secretagogues

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United States of America Patent

APP PUB NO 20070032420A1
SERIAL NO

11352455

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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In general this invention can be viewed as encompassing novel methods of treating diabetes and insulin resistance. The inventors have made the discovery that increasing secretion of endogenous glucagon-like peptide-1 (GLP-1) in combination with inhibiting the activity of dipeptidyl peptidase I (DPP-IV) can have a significant impact on hyperglycemia and insulin secretion in subjects suffering from diabetes and/or insulin resistance. Further the invention encompasses methods of identifying subjects having elevated secretion of GLP-1, methods of assessing sensitivity to a GLP-1 secretagogue, and methods of treating diabetes in these subjects by administering a GLP-1 secretagogue to alleviate at least one symptom of diabetes.

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Patent Owner(s)

Patent OwnerAddress
ENTELOS INC110 MARCH DRIVE FOSTER CITY CA 94404

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Polidori, David Rancho Sante Fe, CA 8 450
Siler, Scott Hayward, CA 6 79

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