Novel F-18 labeled annexin V, synthesis thereof, and use thereof
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United States of America Patent
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Issued Date -
Feb 8, 2007
app pub date -
Dec 22, 2003
filing date -
Jan 2, 2003
priority date (Note) -
Abandoned
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Abstract
A method for noninvasive measurement of apoptosis is described. The method includes the steps of labeling Annexin V with a positron emitter, injecting the labeled Annexin V into a target cell group, obtaining an image of the target cell group using a positron emission tomography scanner, and evaluating the image to determine an amount of cell death within the target cell group. The target cell group may be a lesion or a suspected tumor. The positron emitter may be F-18. The step of labeling Annexin V with F-18 may include the steps of selecting an F-18 labeled small molecule containing a protein conjugating group, synthesizing and purifying the selected molecule, producing a high specific activity prosthetic group as a result of the synthesizing and purifying step, and conjugating the prosthetic group to the Annexin V. The produced prosthetic group may be N-succinimidyl-4-[.sup.18F]fluorobenzoate (SFB).
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