Quinoline derivatives and quinazoline derivatives
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United States of America Patent
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app pub date -
Sep 26, 2006
filing date -
Jan 22, 1999
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Abstract
An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R.sup.1 to R.sup.3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R.sup.4 represents H; R.sup.5 to R.sup.8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R.sup.5 to R.sup.8 do not simultaneously represent H; R.sup.9 and R.sup.10 represent H, alkyl, or alkylcarbonyl; and R.sup.11 represents alkyl, alkenyl, alkynyl, or aralkyl.
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