Taxoid derivative covalently linked to tumor-specific antibody and a method for preparing the same
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United States of America Patent
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Issued Date -
Feb 1, 2007
app pub date -
Sep 7, 2005
filing date -
Aug 1, 2005
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Abstract
To provide a taxoid derivative that has improved solubility in water and acts specifically with respect to tumors, thereby mitigating side effects. The present invention provides an anticancer agent comprises covalent bond compound of an antibody that reacts specifically with respect to cancer cells with a taxoid derivative and a method for preparing the anticancer agent according to claim 1, characterized by reacting, in the presence of reduction agent, an antibody that reacts specifically with respect to cancer cells with a reaction product obtained by allowing periodic acid or periodate to act on a taxoid derivative.
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