Snapback oligonucleotide probe
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United States of America Patent
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Issued Date -
Jan 25, 2007
app pub date -
May 10, 2006
filing date -
May 11, 2005
priority date (Note) -
Abandoned
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Abstract
The invention relates to compositions and methods for detection of specific nucleic acid sequences during an amplification reaction. The invention further relates to a kit format of said compositions for detection of nucleic acid sequences. The Snapback oligonucleotide probes of the invention comprise a target binding sequence, a hairpin forming sequence, and a reporter binding sequence. The action of a nucleic acid polymerase or a flap endonuclease cleaves off a 'snapback segment' of the probe containing the hairpin forming sequence and reporter binding sequence, causing the probe to 'snap back' and form a hairpin structure. The further action of a nucleic acid polymerase or a flap endonuclease cleaves off a label moiety from a reporter oligonucleotide hybridized to the reporter binding sequence, resulting in a detectable signal.
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