Endothelial cell specific antibodies and uses thereof
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United States of America Patent
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Issued Date -
Jan 25, 2007
app pub date -
Mar 4, 2004
filing date -
Mar 4, 2003
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Abandoned
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Abstract
Methods and composition provided herein relate to the inhibition of proliferation, migration, and tubule formation of cells and are thus useful in treating angiogenesis associated diseases, including cancer, polycystic kidney disease, diabetic retinopathy, rheumatoid arthritis, and psoriasis. Disclosed are methods of inhibiting endothelial cell proliferation, migration, and tubule formation by administering an antibody specific for Tumor EndothPelial Markers (TEMs). Also disclosed are methods of inhibiting angiogenesis and tumor growth by administering a TEM-specific antibody and antibody compositions useful in such methods.
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