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Abstract

This invention relates to compounds of formula (I) which are glyoxalase I inhibitors, pharmaceutical salts or compositions comprising such compounds, and the use of such compositions and compounds to treat various conditions alleviated by the inhibition of glyoxalase 1. Wherein X is N or CH. R.sup.2 is H, CF.sub.3; or optionally substituted C.sub.5-6 aryl, C.sub.3-7 cycloalkyl, C.sub.5-7 heterocyclyl. R.sup.3 is H; or optionally substituted C.sub.5-6 aryl, C.sub.3-7 cycloalkyl, C.sub.5-7 heterocyclyl. Alternatively R.sup.2 and R.sup.3 together form an optionally substituted C.sub.3-4alkylene group wherein L.sup.3 and L.sup.4 are single bonds thus forming a C.sub.5-6 ring fused with the aromatic ring to which L.sup.3 and L.sup.4 are attached. L.sup.3 and L.sup.4 are independently selected from a single bond, optionally substituted C.sub.1-4 alkylene, -L.sup.9YN(OH)C(.dbd.O)L.sup.10- and -L.sup.9C(.dbd.O)N(OH)YL.sup.10-, wherein L.sup.9 and L.sup.10 are independently selected from optionally substituted C.sub.1-4 alkylene, C.sub.5-6 arylene, C.sub.1-4 alkylene-C.sub.5-6arylene and a single bond, wherein Y is NH or a single bond.

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First Claim