Conformer-specific antibodies and method of use, thereof
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United States of America Patent
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Issued Date -
Jan 18, 2007
app pub date -
Jun 22, 2006
filing date -
Jun 22, 2005
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Abandoned
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Abstract
A number of polypeptides exist in different three-dimensional conformations, or 'conformers,' which have different biological functions despite having the same or substantially the same primary polypeptide sequences. The existence of different polypeptide conformers underlies to a variety of disease states, which may be assessed using antibody that is specific for a given conformer. Thus, such antibody thus is useful for identifying or detecting certain conformers within a mixed population of conformers.
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