Boat tropanes
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United States of America Patent
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Issued Date -
Jan 11, 2007
app pub date -
Sep 8, 2006
filing date -
Nov 3, 1995
priority date (Note) -
Abandoned
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Abstract
Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.
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