212Bi or 213Bi Generator from supported parent isotope
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United States of America Patent
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Issued Date -
Jan 11, 2007
app pub date -
Jul 11, 2005
filing date -
Jul 11, 2005
priority date (Note) -
Abandoned
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Abstract
The invention includes a radionuclide generator having an ion exchange sorbent that comprises oxygen-containing functional groups grafted by organic linking groups to an inorganic oxygen-linked network and a parent isotope. For .sup.212Bi or .sup.213Bi generators, the parent isotope may be .sup.224Ra, .sup.225Ra or .sup.225Ac. The surface area of the sorbent is preferably less than about 10 m.sup.2/g and more preferably less than about 1 m.sup.2/g. The exchange sorbent may be formed of any covalently bonded inorganic oxide that is capable of forming oxygen-linked networks. The oxidized functional groups may include sulfonato groups, may include moieties selected from --SO.sub.3H, --SO.sub.3Na, --SO.sub.3K, --SO.sub.3Li, --SO.sub.3NH.sub.4 or may include moieties selected from --PO(OX).sub.2 or --COOX, wherein X is selected from H, Na, K or NH.sub.4 or combinations thereof. A .sup.213Bi or .sup.212Bi generator process includes eluting .sup.213Bi or .sup.212Bi with an aqueous solvent that includes .sup.225Ac or .sup.225Ra or .sup.224Ra on the above support medium.
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