Silylated oligonucleotide compounds
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United States of America Patent
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Issued Date -
Jan 4, 2007
app pub date -
Mar 19, 2004
filing date -
Mar 24, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Oligonucleotide comprising at least one internucleotide phosphorus atom protected with a group of formula --X.sup.aSiR.sup.3R.sup.4R.sup.5 provided. X.sup.a represent 0 or S, and R.sup.3, R.sup.4 and R.sup.5 each independently are optionally substituted hydrocarbyl groups, selected such that that total number of carbon atoms in R.sup.3 plus R.sup.4 plus R.sup.5 is 4 or more. Process for the preparation of these oligonucleotides, intermediate compounds useful therein, and process for the preparation of the intermediate compounds are also provided.
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