Aryl Phosphate Derivatives of d4T
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United States of America Patent
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Issued Date -
Dec 28, 2006
app pub date -
Dec 9, 2005
filing date -
Nov 13, 2000
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Abstract
Specific aryl phosphate nucleoside derivatives show activity against HIV without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse transcriptase. Examples of aryl phosphate nucleoside derivatives include aryl phosphate derivatives of d4T having one or more substituents on the aryl group, and wherein the phosphorus of the aryl phosphate group is attached to an amino acid residue that may be esterified or substituted, such as a methoxyalaninyl group.
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