Hgf production accelerator containing heparin-like oligosaccharide
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United States of America Patent
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Issued Date -
Dec 28, 2006
app pub date -
Mar 28, 2005
filing date -
Mar 29, 2004
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Abandoned
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Abstract
The present invention aims to provide an agent for promoting HGF production comprising, as an effective ingredient, a disaccharide comprised of an uronic acid residue (wherein an uronic acid means an iduronic acid or a glucuronic acid, and has the same meaning hereinafter) and a glucosamine residue that are connected by .alpha.1,4-glycosidic linkage or .beta.1,4-glycosidic linkage, or an oligosaccharide of tri- to hexadeca-saccharides having a structure in which uronic acid residues and glucosamine residues are alternately and repeatedly connected by .alpha.1,4-glycosidic linkage or .beta.1,4-glycosidic linkage, wherein at least one hydroxy group of the uronic acid residues and/or the glucosamine residues may be sulfated, alkylated, acylated or aminated, and/or the amino group at position 2 of at least one of the glucosamine residue(s) may be sulfated, alkylated or acylated, or a salt thereof. The agent of the present invention for promoting HGF production is useful to promote healing of damaged tissues or organs of a living body.
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