Method for in vitro detection aberrant dysplasia, and the artificial nucleotides being used
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United States of America Patent
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Issued Date -
Nov 9, 2006
app pub date -
Mar 13, 2003
filing date -
Mar 13, 2003
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Abstract
The present invention provides a method for in vitro detection of malignant potential of dysplasia by aberrant methylation of p16 CpG islands, comprising extraction of genomic DNA from a tissue or body fluid sample, analysis of methylation status of p16 CpG islands in the extracted DNA, and evaluation of malignant potential of the tested tissue. The present invention also provides DNA compositions having artificial sequences of p16 CpG islands with or without methylation.
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