Methods for improving cell therapy and tissue regeneration in patients with cardiovascular and neurological diseases by means of shockwaves

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United States of America Patent

SERIAL NO

11304865

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Abstract

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Improving cell therapy and tissue regeneration in a patient suffering from a cardiovascular or a neurological disease by treating a tissue of the patient with shock waves and/or applying to the patient a therapeutically effective amount of stem cells and/or progenitor cells. Such treatment increases expression of chemoattractants, pro-angiogenic factors, and pro-survival factors. The chemoattractants can be, for example, vascular endothelial growth factor (VEGF) or stromal cell derived factor 1 (SDF-1). For example, the treated tissue can be located in the patient's heart or in a skeletal muscle of the patient, and the shock waves can be extracorporeal shock waves (ESW) or intracorporeal shock waves. The cardiovascular disease can have an ischemic or non-ischemic etiology. For example, the cardiovascular disease can be a myocardial infarction, ischemic cardiomyopathy, or a dilatative cardiomyopathy. For example, the neurological disease can be a peripheral neuropathy or neuropathic pain.

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Patent Owner(s)

Patent OwnerAddress
DORNIER MEDTECH SYSTEMS GMBH82234 WESSLING

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aicher, Alexandra Frankfurt, DE 2 35
Dimmeler, Stefanie Frankfurt, DE 21 190
Eizenhofer, Harald Seefeld, DE 11 199
Heeschen, Christopher US 17 198
Lutz, Andreas Seefeld, DE 122 1158
Zeiher, Andreas Michael Frankfurt, DE 2 35

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