Method for generating high affinity antibodies
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United States of America Patent
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Issued Date -
Oct 19, 2006
app pub date -
Feb 2, 2004
filing date -
Feb 1, 2003
priority date (Note) -
Abandoned
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Abstract
The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
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