Novel mechanism for hiv-1 entry into host cells and peptides inhibiting this mechanism
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United States of America Patent
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Issued Date -
Oct 19, 2006
app pub date -
Sep 12, 2003
filing date -
Sep 13, 2002
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Abandoned
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Abstract
This invention relates to the finding that TAT interacts with gp120 at the cell surface and enhances HIV-1 entry into host cells. This invention also discloses modulators of this interaction, particularly peptides that mimic the region of gp120 involved in this interaction. These peptides interfere with TAT-mediated enhancement of infection regardless of virus strain, and are therefore suitable for the development in general of broad-range drugs against AIDS and other infectious diseases induced by HIV-1 related pathogens, and specifically for a class of chemicals active in the reduction or abrogation of virus and infectivity spreading.
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