High affinity oligonucleotide ligands to growth factors
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United States of America Patent
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May 31, 2006
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Jun 2, 1995
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Abstract
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF.beta., PDGF and hKGF. Included in the invention are specific RNA and ssDNA ligands to TGF.beta.1 and PDGF identified by the SELEX method. Also included in the invention are specific RNA ligands to hKGF identified by the SELEX method. Further included are RNA ligands that inhibit the interaction of TGF.beta.1 and hKGF with their receptors and DNA ligands that inhibit the interaction of PDGF with its receptor.
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