Sustained release of microcrystalline peptide suspensions
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United States of America Patent
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Issued Date -
Oct 12, 2006
app pub date -
Jun 12, 2006
filing date -
Sep 6, 2001
priority date (Note) -
Abandoned
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Abstract
The invention relates to a fluid, milky microcrystalline aqueous suspension of a peptide or peptidomimetic and a counter-ion of a strong proton donor in water, wherein the peptide or peptidomimetic and counter-ion are present in amounts and at a molar ratio sufficient to form the suspension upon mixing and without formation of a gel. The invention also relates to lyophilized compositions that include a dried suspension, methods of making the lyophilized composition, methods of preparing the suspension, and sustained release formulations prepared by the methods.
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