Cyclic tetrapeptide compound and use thereof
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United States of America Patent
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N/A
Issued Date -
Oct 12, 2006
app pub date -
Dec 27, 2002
filing date -
Dec 28, 2001
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
A cyclic tetrapeptide compound of the formula (I): wherein R.sub.1 is hydrogen; R.sub.2 is lower alkyl, aryl, optionally substituted ar(lower)alkyl, heterocyclic(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, lower alkylcarbamoyl(lower)alkyl or arylcarbamoyl(lower)alkyl; R.sub.3 and R.sub.4 are each independently hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic(lower)alkyl or cyclo(lower)alkyl(lower)alkyl, or R.sub.3 and R.sub.4 are linked together to form lower alkylene or condensed ring, or one of R.sub.3 and R.sub.4 is linked to the adjacent nitrogen atom to form a ring; R.sub.5 is lower alkylene or lower alkenylene, Y is [wherein R.sub.Y1 is hydrogen, halogen or optionally protected hydroxy, R.sub.Y2 is hydrogen, halogen, lower alkyl or phenyl, and R.sub.Y3 is hydrogen or lower alkyl]; R.sub.8 is hydrogen or lower alkyl; and n is an integer of 1 or 2, or a salt thereof.
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