Homologous recombination in multipotent adult progenitor cells
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United States of America Patent
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Issued Date -
Oct 12, 2006
app pub date -
Nov 25, 2003
filing date -
Nov 27, 2002
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Abandoned
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Abstract
The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.
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