Importance

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Abstract

A compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein Ar is a substituted heteroaryl group bearing at least one nitro or azido group or is a group of formula (2) or (3); R1 is hydrogen, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R.sub.2 is alkyl, alkoxy, thialkoxy or halo; R.sub.3, R.sub.4 and R.sub.5 are each independently alkyl, alkoxy, thialkoxy or halo with the proviso that at least two of R.sub.3, R.sub.4 or R.sub.5 are alkoxy; L is --OC(O)-- or --OP(O)(OR.sub.6)--; n is 0 or 1; X is O, S or NR.sub.7; Y is hydrogen, alkyl, alkoxy, thialkoxy, halo, hydroxy or dihydrogenphosphate; R.sub.6 is hydrogen or alkyl; R.sub.7 is hydrogen or alkyl; R.sub.8 is hydrogen, alkoxy or dialkylaminoalkyl; R.sub.9 is optionally substituted alkyl; R.sub.10 is hydrogen, alkyl, alkoxy or dialkylaminoalkyl; R.sub.11, and R.sub.12 are independently hydrogen, alkyl, alkoxy, thialkoxy, amono alkylamino, dialkylamino, morpholino, alkylmorpholino, piperidino, alkylpiperidiono, piperazino, alkylpiperazino or 1-aziridinyl; and A, together with the carbon atoms to which it is fused, is an optionally substituted aryl or heteroaryl ring.

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First Claim