Detoxified TNF and method of preparing
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United States of America Patent
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app pub date -
Nov 9, 2005
filing date -
May 9, 2003
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Abstract
The present invention provides for an immunogenic analogue of a human TNF.alpha. protein, wherein said analogue comprises an immunogenized monomeric TNF.alpha. polypeptide or TNF.alpha. di- or timer, and wherein the analogue further comprises a toxicity reducing or abolishing mutation selected from the group consisting of Y87S, D143N or A145R, the amino acid numbering setting out from the N-terminal valine in human TNF.alpha.. The invention also provides for a nucleic acid fragment encoding the analogue as well as to vectors and transformed cells useful in the preparation of the analogue. Also disclosed are methods of down-regulating TNF.alpha. in a subject in need thereof.
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